- Development of protocols and methodologies for genetic manipulations of Streptomyces spp (non GMO, GMO)
- Mutation and overexpression of genes involved in the biosynthesis of metabolites and/or precursors through knocking-out and/or knocking-in
- Identification of regulatory networks and/or molecular pathways involved in the biosynthesis of metabolites and/or precursors by ‘omics’ technologies
- Metabolic Engineering
- Synthetic biology: targeted amplification, DNA synthesis
- Productivity testing of mutants obtained (non GMO/GMO); lab scale, bench scale
- Media and Process development to maximize metabolites productivity by fermentation of Streptomyces spp strains wild type and overproducers (non GMO, GMO)
- Development of protocols and methodologies for footprint improvement: bioconversions, solvent reduction, waste reduction, energy reduction
- Genetic characterization of microbial population from waste water treatment plant
- Effects of metabolites over microbial vitality and metabolism
- Prototype waste process execution
